Abstract
A CXCR3 pocket capable of accommodating polycycloaliphatics was explored using a modular synthetic strategy. The systematic studies reveal that the tricyclic 2-adamantane and bicyclic (iso)bornyl group are efficiently recognized by CXCR3.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adamantane / chemistry
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Amination
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Binding Sites / physiology
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Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis
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Camphanes / chemistry
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Cell Line
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Humans
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Polycyclic Compounds / chemical synthesis*
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Polycyclic Compounds / metabolism*
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Receptors, CXCR3 / chemistry
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Receptors, CXCR3 / metabolism*
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Structure-Activity Relationship
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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CXCR3 protein, human
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Camphanes
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Polycyclic Compounds
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Receptors, CXCR3
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camphane
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Adamantane